منابع مشابه
Spindle pole bodies
How did you become interested in plants? I began my graduate work with Phil Leder with the hope of making transgenic mice as a means towards understanding development in a multicellular organism. It turned out to be far more difficult and timeconsuming than I had bargained for. So when it became apparent that making transgenic plants was relatively easy, I jumped at the opportunity. I also thou...
متن کاملCsi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation
Accurate chromosome segregation requires timely bipolar spindle formation during mitosis. The transforming acidic coiled-coil (TACC) family proteins and the ch-TOG family proteins are key players in bipolar spindle formation. They form a complex to stabilize spindle microtubules, mainly dependent on their localization to the centrosome (the spindle pole body [SPB] in yeast). The molecular mecha...
متن کاملBuilding a spindle pole
astillo et al. (page 453) have identified what may be a key event in building the spindle pole body (SPB) of budding yeast. They found that the kinase Mps1p phosphorylates and thus helps organize Spc42p, an important component of the SPB central plaque. Mps1p has been a difficult protein to study, as it does double duty as a regulator of SPB structure, and as part of the spindle checkpoint sign...
متن کاملStable reanaphase spindle positioning requires Bud6p and an apparent interaction between the spindle pole bodies and the neck
Stable reanaphase spindle positioning requires Bud6p and an apparent interaction between the spindle pole bodies and the neck.
متن کاملTem1 localization to the spindle pole bodies is essential for mitotic exit and impairs spindle checkpoint function
The mitotic exit network (MEN) is a signaling cascade that triggers inactivation of the mitotic cyclin-dependent kinases and exit from mitosis. The GTPase Tem1 localizes on the spindle pole bodies (SPBs) and initiates MEN signaling. Tem1 activity is inhibited until anaphase by Bfa1-Bub2. These proteins are also part of the spindle position checkpoint (SPOC), a surveillance mechanism that restra...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2013
ISSN: 0960-9822
DOI: 10.1016/j.cub.2013.07.024