Spinal NKCC1 Blockade Inhibits TRPV1-Dependent Referred Allodynia
نویسندگان
چکیده
منابع مشابه
Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia
BACKGROUND The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult. The NKCC1 cotransporter regulates intracellular [Cl-] and thus the magnitude and polarity of GABAA receptor responses in neurons. TRPV1 receptors transduce diverse chemical and natural stimuli in nocice...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2007
ISSN: 1744-8069,1744-8069
DOI: 10.1186/1744-8069-3-17