Sphingomyelinase D from Loxosceles laeta Venom Induces the Expression of MMP7 in Human Keratinocytes: Contribution to Dermonecrosis
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منابع مشابه
Loxosceles laeta venom in rabbits
5 Guilherme Martins1, Maira Oliveira1, Ana Flávia Botelho1, Conrado Gamba2, Clara Duarte3, 6 Adriane Bicalho1, Geovanni Cassali2, Alfredo Goes2, Carlos Chávez-Olórtegui2, Benito 7 Soto-Blanco1 and Marilia Melo1* 8 9 1 Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas 10 Gerais, Brazil; [email protected] (GM); [email protected] (MO);...
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Cutaneous loxoscelism envenomation by Loxosceles spiders is characterized by the development of a dermonecrotic lesion, strong inflammatory response, the production of pro-inflammatory mediators, and leukocyte migration to the bite site. The role of phospholipase D (PLD) from Loxosceles in the recruitment and migration of monocytes to the envenomation site has not yet been described. This study...
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The human complement system is composed of more than 30 proteins and many of these have conserved domains that allow tracing the phylogenetic evolution. The complement system seems to be initiated with the appearance of C3 and factor B (FB), the only components found in some protostomes and cnidarians, suggesting that the alternative pathway is the most ancient. Here, we present the characteriz...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0153090