Speeding Towards the Goal That We Set Out

Speeding Towards the Goal That We Set Out

Towards goal-directed therapy of hepatorenal syndrome: we have the tools but we need the trials

Patients with cirrhosis who develop tense ascites and hepatorenal syndrome have a very high mortality and present a management challenge. Current debate stems from a lack of studies evaluating changes in effective arterial blood volume following paracentesis or targeting fluid replacement with appropriate vascular physiological measures to ensure no paracentesis-related circulatory dysfunction....

GOAL: What Have We Learned?

A recent study entitled “Can Guideline-Defined Asthma Control Be Achieved?”1 stands out as one of the most noteworthy clinical studies of the past year because of the important concepts it confirms and because of the many significant questions it raises. Published online in July 2004 and in print in October of the same year, it is referred to by most as the GOAL trial (from the now familiar acr...

Can we cut out the meat of the dish? Constructing consumer-oriented pathways towards meat substitution.

The shift towards a more sustainable diet necessitates less reliance on foods of animal origin. This study presents data from a representative survey of Dutch consumers on their practices related to meat, meat substitution and meat reduction. The practices reflected a cultural gradient of meat substitution options running from other products of animal origin and conventional meat free meals to ...

Automated Agents that Proficiently Negotiate with People: Can We Keep People out of the Evaluation Loop

Research on automated negotiators has flourished in recent years. Among the important issues considered is how these automated negotiators can proficiently negotiate with people. To validate this, many experimentations with people are required. Nonetheless, conducting experiments with people is timely and costly, making the evaluation of these automated negotiators a very difficult process. Mor...