Specificity of Heteroantisera to Human Acute Leukemia-Associated Antigens

Specificity of heteroantisera to human acute leukemia-associated antigens.

Antisera have been raised to human leukemic blast cells from individual patients in mice rendered tolerant with cyclophosphamide to remission leukocytes from the same individual. 10 antisera were raised against acute myelogenous leukemia (AML) cells and 5 antisera were raised against acute lymphoblastic leukemia (ALL) cells. Antisera to AML cells were absorbed with ALL cells, and antisera to AL...

Human leukemia-lymphoma associated antigen detected by heteroantisera.

Immunotherapy of human acute leukemia: antibody response to leukemia-associated antigens.

We studied the hormonal antibody response to leukemia-associated antigens in patients with acute myeloblastic leukemia (AML) receiving immunotherapy and examined the relationship of antibody production to patient survival. Sixteen adult patients with AML in complete remission were given weekly immunotherapy in addition to monthly remission maintenance chemotherapy. Immunotherapy consisted of in...

Nonhuman primates express human leukemia-associated antigens.

Serologic studies using four murine monoclonal antibodies specific for the common acute lymphoblastic leukemia antigen (CALLA) and five monoclonal antibodies specific for the gp24 surface antigen indicate that these leukemia-associated antigens are present on cells of comparable tissues in man and in four nonhuman primates. As in man, adherent cell populations obtained from skin, lung, and bone...

Expression of normal myeloid-associated antigens by acute leukemia cells.

Monoclonal antibodies that react with hematopoietic cells and their precursors in a stage and lineage restricted fashion were used in indirect immunofluorescence assays to examine leukemic cells from 105 pediatric age patients. The differentiative states of blasts from 42 patients with acute nonlymphocytic leukemia (ANLL) were defined by these antibodies. When these were compared to their morph...