Specification of the Cardiac Conduction System by Transcription Factors
نویسندگان
چکیده
منابع مشابه
Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system.
The cardiac conduction system consists of distinctive heart muscle cells that initiate and propagate the electric impulse required for coordinated contraction. The conduction system expresses the transcriptional repressor Tbx3, which is required for vertebrate development and controls the formation of the sinus node. In humans, mutations in Tbx3 cause ulnar-mammary syndrome. Here, we investigat...
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15 صفحه اولLineages of the Cardiac Conduction System
The cardiac conduction system (CCS) initiates and coordinately propagates the electrical impulse to orchestrate the heartbeat. It consists of a set of interconnected components with shared properties. A better understanding of the origin and specification of CCS lineages has allowed us to better comprehend the etiology of CCS disease and has provided leads for development of therapies. A variet...
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The heterogeneous tissues of the cardiac pacemaking and conduction system are responsible for setting, maintaining and coordinating the rhythmic pumping of the heart (reviewed Thompson et al., 1995; Moorman et al., 1998; Gourdie et al., 1999). Anomalous development of this specialized network has been implicated in pediatric arrhythmia and other congenital abnormalities of cardiac activation (S...
متن کاملDevelopment of the cardiac conduction system.
The cardiac conduction system (CCS) is a specialized tissue network that initiates and maintains a rhythmic heartbeat. The CCS consists of several functional subcomponents responsible for producing a pacemaking impulse and distributing action potentials across the heart in a coordinated manner. The formation of the distinct subcomponents of the CCS occurs within a precise temporal and spatial f...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2009
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.109.204123