Species Specificity in Reaction between Renin and Angiotensinogen
نویسندگان
چکیده
منابع مشابه
Kinetics of the Reaction Between Mouse Renin and Rat Angiotensinogen
The transgenic rat TGR(mRen-2)27, in which the Ren-2 mouse renin gene is transfected into the genome of the rat, develops severe hypertension with high adrenal renin and low kidney renin. These animals express both mouse and rat renin. To investigate the cause of hypertension in the TGR rat, we compared the kinetics of mouse renin acting on mouse and rat angiotensinogens. The optimum pH of the ...
متن کاملKinetic Constants of the Human Renin and Human Angiotensinogen Reaction
The rate of formation of angiotensin was investigated for the reaction of angiotensinase-free human renin, at various states of purity, with angiotensinogen, in pooled, angiotensinase-free human serum. The velocity constant of this reaction and the Michaelis constant of the rerun-substrate complex were determined. The concentration of angiotensinogen and of endogenous renin in human serum was a...
متن کاملKinetic constants of the human renin and human angiotensinogen reaction.
The rate of formation of angiotensin was investigated for the reaction of angiotensinase-free human renin, at various states of purity, with angiotensinogen, in pooled, angiotensinase-free human serum. The velocity constant of this reaction and the Michaelis constant of the rerun-substrate complex were determined. The concentration of angiotensinogen and of endogenous renin in human serum was a...
متن کاملSer84 of human renin contributes to the biphasic pH dependence of the renin-angiotensinogen reaction.
The pH dependence of the reaction of various renins was investigated using sheep angiotensinogen as a substrate. Human renin showed two separate peaks, but rat and mouse Ren1 renins showed one peak with a shoulder. A comparison of the predicted subsite residues of human renin with those of rat and mouse Ren1 renins revealed that Arg82, Ser84, Thr85, Ala229, and Thr312 are unique in the human se...
متن کاملCerebral arteriolar structure in mice overexpressing human renin and angiotensinogen.
We examined the hypothesis that the renin-angiotensin system plays an important role in vascular remodeling (defined as reduced external diameter) during chronic hypertension. We measured pressure, diameter, and cross-sectional area of the vessel wall in maximally dilated cerebral arterioles in transgenic mice that overexpress both human renin and human angiotensinogen and in spontaneously hype...
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ژورنال
عنوان ژورنال: Nature
سال: 1965
ISSN: 0028-0836,1476-4687
DOI: 10.1038/207636a0