منابع مشابه
Specialized chaperones
A n interphase meeting between X chromosomes, revealed by Na Xu, Chia-Lun Tsai, and Jeannie Lee (Harvard Medical School, Boston, MA), ensures that one and only one is silenced. Silencing of one of the two X chromosomes in a female somatic cell brings the gene dosage level down to that of male cells. Inactivation is controlled by several noncoding RNAs transcribed from, and acting in cis upon, t...
متن کاملSpecialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER
The integral endoplasmic reticulum (ER) membrane protein Shr3p is required for proper plasma membrane localization of amino acid permeases (AAPs) in yeast. In the absence of Shr3p AAPs are uniquely retained in the ER with each of their twelve membrane-spanning segments correctly inserted in the membrane. Here, we show that the membrane domain of Shr3p specifically prevents AAPs from aggregating...
متن کاملType III chaperones & Co in bacterial plant pathogens: a set of specialized bodyguards mediating effector delivery
Gram-negative plant pathogenic bacteria possess a type III secretion system (T3SS) to inject bacterial proteins, called type III effectors (T3Es), into host cells through a specialized syringe structure. T3Es are virulence factors that can suppress plant immunity but they can also conversely be recognized by the plant and trigger specific resistance mechanisms. The T3SS and injected T3Es play a...
متن کاملExtracellular chaperones.
The maintenance of the levels and correct folding state of proteins (proteostasis) is a fundamental prerequisite for life. Life has evolved complex mechanisms to maintain proteostasis and many of these that operate inside cells are now well understood. The same cannot yet be said of corresponding processes in extracellular fluids of the human body, where inappropriate protein aggregation is kno...
متن کاملMolecular Chaperones
In most cases proteins fold spontaneously under physiological conditions and do not require any external assistance. This has become evident since the experiments on ribonuclease A conducted by Anfinsen in ‘50s and ‘60s. The list of such “successful” folders has grown since and now includes many two-state proteins catalogued in Folding & Design 3, R81. These proteins fold rapidly and reliably t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1724rr3