Special edition update on postmenopausal osteoporosis
نویسندگان
چکیده
منابع مشابه
Update on postmenopausal osteoporosis management.
One in two women has a fracture after the age of 50;1 most will be osteoporotic. Fracture incidence will probably increase as people live longer. After hip fracture there is 20% mortality within three months2 and increased disability, with >50% of people who previously walked unaided needing aids and >50% requiring help at home.3 Morbidity, disability and dependence increase progressively with ...
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Denosumab, a fully human recombinant monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL), blocks binding of RANKL to the RANK receptor, found on the surface of osteoclasts and osteoclast precursors, resulting in decreased bone resorption. Subcutaneous denosumab administration once every 6 months increases bone mineral density at the lumbar spine, total hip, and/or ...
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Osteoporosis is a condition of low bone mass which predisposes to fractures. This silently progressive metabolic bone disease is widely prevalent in India in both sexes and occurs at younger age than in western population. Rapid bone loss occurs in postmenopausal women due to hormonal factors. Indians have low bone density compared to Caucasians. High prevalence of vitamin D deficiency is a maj...
متن کاملUpdate on denosumab in the management of postmenopausal osteoporosis: patient preference and adherence
Patient adherence to many osteoporosis treatments, primarily bisphosphonates, is generally poor, thus leading to a significant reduction in antifracture efficacy. Patient perceptions about the necessity of the prescribed medication to treat osteoporosis and the concerns about the potential adverse effects are important and potentially modifiable determinants of adherence, in addition to other f...
متن کاملUpdate on long-term treatment with bisphosphonates for postmenopausal osteoporosis: a systematic review.
INTRODUCTION Osteoporosis is a progressive skeletal disorder that requires long-term treatment. However, there is little guidance regarding optimal treatment duration and what the treatment discontinuation and retreatment criteria should be. Given that bisphosphonates are the most commonly prescribed class of agent for the treatment of osteoporosis, we reviewed the long-term data relating to th...
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ژورنال
عنوان ژورنال: Reviews in Endocrine and Metabolic Disorders
سال: 2010
ISSN: 1389-9155,1573-2606
DOI: 10.1007/s11154-010-9155-z