Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes

Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes

Type 1 diabetes (T1D) is an auto-immune disease characterized by the selective destruction of the insulin secreting beta cells in the pancreas during an inflammatory phase known as insulitis. Patients with T1D are typically dependent on the administration of externally provided insulin in order to manage blood glucose levels. Whilst technological developments have significantly improved both th...

Functional Imaging of Insulitis in Type 1 Diabetes

Insulitis in Type 1 Diabetes: A Sticky Problem

Lymphocytic infiltration in the islets of Langerhans is generally recognized as the defining lesion in young patients with recent-onset type 1A diabetes. In a landmark article published in Diabetes in 1965, Gepts (1) described insulitis in 70% of cases with acute diabetes and found that the lesion only affected islets with residual -cells in pancreatic organs that had otherwise lost most of the...

prevalence of atopic dermatitis in children with type 1 diabetes mellitus in southeastern of iran (kerman province): a case-control study

چکیده ندارد.

Imaging of β-cell mass and insulitis in insulin-dependent (Type 1) diabetes mellitus.

Insulin-dependent (type 1) diabetes mellitus is a metabolic disease with a complex multifactorial etiology and a poorly understood pathogenesis. Genetic and environmental factors cause an autoimmune reaction against pancreatic β-cells, called insulitis, confirmed in pancreatic samples obtained at autopsy. The possibility to noninvasively quantify β-cell mass in vivo would provide important biol...