Spatial diversity: Ras trafficking and signalling
نویسندگان
چکیده
منابع مشابه
Compartmentalized signalling of Ras.
Ras proteins associate with cellular membranes by virtue of a series of post-translational modifications of their C-terminal CAAX sequences. The discovery that two of the three enzymes that modify CAAX proteins are restricted to the endoplasmic reticulum led to the recognition that all nascent Ras proteins transit endomembranes en route to the PM (plasma membrane) and that at steady-state N-Ras...
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RAS proteins are key signalling hubs that are oncogenically mutated in 30% of all cancer cases. Three genes encode almost identical isoforms that are ubiquitously expressed, but are not functionally redundant. The network responses associated with each isoform and individual oncogenic mutations remain to be fully characterized. In the present article, we review recent data defining the differen...
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ژورنال
عنوان ژورنال: The Biochemist
سال: 2003
ISSN: 0954-982X,1740-1194
DOI: 10.1042/bio02503022