Spatial and temporal evolution of distal 10q deletion, a prognostically unfavorable event in diffuse low-grade gliomas
نویسندگان
چکیده
منابع مشابه
Chromosome 9p and 10q losses predict unfavorable outcome in low-grade gliomas.
The loss of chromosomes 1p-19q is the only prognostic molecular alteration identified in low-grade gliomas (LGGs) to date. Search for loss of heterozygosity (LOH) on chromosomes 1p, 9p, 10q, and 19q was performed in a series of 231 LGGs. Loss of chromosomes 1p-19q was strongly correlated with prolonged progression-free survival (PFS) and overall survival (OS) in univariate and multivariate anal...
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The origins of diffuse low-grade gliomas (DLGG) are unknown. Beyond some limited data on their temporal and cellular origins, the mechanisms and risk factors involved are poorly known. First, based on strong relationships between DLGG development and the eloquence of brain regions frequently invaded by these tumors, we propose a "functional theory" to explain the origin of DLGG. Second, the bio...
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Diffuse low-grade gliomas are highly epileptogenic brain tumours. We aimed to explore the natural course of epileptic seizures, their predictors and the prognostic significance of their occurrence in adult patients harbouring a diffuse low-grade glioma. An observational retrospective multicentre study examined 1509 patients with diffuse low-grade gliomas to identify mutual interactions between ...
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Duffau and colleagues present a comprehensive and provocative review of the concepts of surgical and medical management of adult diffuse low-grade gliomas (DLGG). The review takes a very strong position, which will likely generate debate and stimulate much discussion regarding the establishment of guidelines for care of patients with DLGG. Here we provide a counterpoint to summarize the perspec...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2014
ISSN: 1474-760X
DOI: 10.1186/s13059-014-0471-6