SP558SCLEROSTIN; ANOTHER VASCULAR CALCIFICATION INHIBITOR
نویسندگان
چکیده
منابع مشابه
Dexamethasone downregulates calcification-inhibitor molecules and accelerates osteogenic differentiation of vascular pericytes: implications for vascular calcification.
Vascular calcification is present in many pathological conditions and is recognized as a strong predictor of future cardiovascular events. Current evidence suggests that it is a regulated process involving inducing and inhibitory molecules. Glucocorticoids have great clinical importance as antiinflammatory drugs and can act as potent inducers of osteogenic differentiation in vitro. The effect o...
متن کاملAssociations between Thyroid Hormones, Calcification Inhibitor Levels and Vascular Calcification in End-Stage Renal Disease
INTRODUCTION Vascular calcification is a common, serious and elusive complication of end-stage renal disease (ESRD). As a pro-calcifying risk factor, non-thyroidal illness may promote vascular calcification through a systemic lowering of vascular calcification inhibitors such as matrix-gla protein (MGP) and Klotho. METHODS AND MATERIAL In 97 ESRD patients eligible for living donor kidney tran...
متن کامل[Vascular calcification in CKD].
As doenças cardiovasculares (DCV) constituem a principal causa de mortalidade em pacientes com doença renal crônica (DRC).1 O risco de óbito por DCV nessa população chega a ser 10 a 30 vezes maior que aquele observado na população geral. Esse aumento da mortalidade também ocorre em pacientes nos estágios precoces da DRC,2 assim como naqueles submetidos a transplante renal.3 A alta prevalência d...
متن کاملMagnesium Counteracts Vascular Calcification
Cardiovascular disease is the leading cause of mortality in patients with chronic kidney disease (CKD). Cardiovascular events are 5 to 30× more likely to occur in end-stage renal disease (ESRD) patients compared with the general population of the same age, sex, and race. In dialysis patients, arterial stiffness has been identified as an independent risk factor for cardiovascular mortality. An i...
متن کاملVascular calcification mechanisms.
Vascular calcification is highly correlated with cardiovascular disease mortality, especially in patients with ESRD or diabetes. In addition to the devastating effects of inappropriate biomineralization seen in cardiac valvulopathies, calciphylaxis, and idiopathic arterial calcification, vascular calcification is now recognized as a marker of atherosclerotic plaque burden as well as a major con...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2017
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfx152.sp558