SOX2OT Long Noncoding RNA Is Regulated by the UPR in Oestrogen Receptor-Positive Breast Cancer

Endoplasmic reticulum (ENR) stress perturbs cell homeostasis and induces the unfolded protein response (UPR). In breast cancer, this process is activated by oestrogen deprivation associated with tamoxifen resistance. We present evidence that transcription factor SOX2 long noncoding RNA overlapping transcript (SOX2OT) are upregulated in receptor-positive (ER+) cancer to deprivation. examined effect of UPR on SOX2OT expression pathways lines. The induction thapsigargin or glucose upregulates expression. This upregulation also shown anti-oestrogen 4OH-tamoxifen mTOR inhibitor everolimus ER + cells sensitive treatment. overexpression decreased BiP PERK was confirmed pathway q-PCR. Our results show a regulates evince new function as participant ENR reprogramming cells.