SOX2 haploinsufficiency promotes impaired vision at advanced age
نویسندگان
چکیده
منابع مشابه
SOX2 haploinsufficiency is associated with slow progressing hypothalamo-pituitary tumours
SOX2 is an early developmental transcription factor and marker of stem cells that has recently been implicated in the development of the pituitary gland. Heterozygous SOX2 mutations have been described in patients with hypopituitarism and severe ocular abnormalities. In the majority of published cases, the pituitary gland is either small or normal in size. Here, we report two unrelated patients...
متن کاملAdvanced IT Education for the Vision Impaired via e-Learning
Lack of accessibility in the design of e-learning courses continues to hinder students with vision impairment. E-learning materials are predominantly vision-centric, incorporating images, animation, and interactive media, and as a result students with acute vision impairment do not have equal opportunity to gain tertiary qualifications or skills relevant to the marketplace and their disability....
متن کاملImpaired immune response to vaccination against infection with 3 human respiratory syncytial virus at advanced age
5 Teun Guichelaar#, Jeroen Hoeboer, Myra N. Widjojoatmodjo, Sylvia S.N. Reemers, Cécile 6 A.C.M. van Els, Rob Otten, Yvonne van Remmerden, Jolande Boes, Willem Luytjes 7 8 Centre for Immunology of Infectious Diseases and Vaccinology, National Institute for Health 9 and the Environment, 3720 BA Bilthoven, The Netherlands 10 11 Present address: Crucell, Leiden, The Netherlands 12 Present address:...
متن کاملImpaired immune response to vaccination against infection with human respiratory syncytial virus at advanced age.
UNLABELLED Elderly humans are prone to severe infection with human respiratory syncytial virus (HRSV). The aging of today's human population warrants the development of protective vaccination strategies aimed specifically at the elderly. This may require special approaches due to deteriorating immune function. To design and test vaccination strategies tailored to the elderly population, we need...
متن کاملPulsar Death at an Advanced Age
I summarize the theory of acceleration of non-neutral particle beams by starvation electric fields along the polar magnetic field lines of rotation powered pulsars, including the effect of dragging of inertial frames which dominates the acceleration of a space charge limited beam. I apply these results to a new calculation of the radio pulsar death line, under the hypotheses that pulsar “death”...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2018
ISSN: 1949-2553
DOI: 10.18632/oncotarget.26393