منابع مشابه
Sorting out sortilin.
G association studies have the potential to lead to identification of novel pathways and mechanisms for the pathogenesis of common complex diseases. Previous genome-wide association studies have identified a locus on 1p13 as a risk locus for dyslipidemia and myocardial infarction. However, the responsible mechanisms have remained elusive. Two recent reports implicate SORT1 as the causative gene...
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Sonic Hedgehog (Shh) is a secreted morphogen that is an essential regulator of patterning and growth. The Shh full-length protein undergoes autocleavage in the endoplasmic reticulum to generate the biologically active N-terminal fragment (ShhN), which is destined for secretion. We identified sortilin (Sort1), a member of the VPS10P-domain receptor family, as a new Shh trafficking receptor. We d...
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Prion diseases are a group of fatal neurodegenerative disorders caused by prions, which consist mainly of the abnormally folded isoform of prion protein, PrPSc. A pivotal pathogenic event in prion disease is progressive accumulation of prions, or PrPSc, in brains through constitutive conformational conversion of the cellular prion protein, PrPC, into PrPSc. However, the cellular mechanism by wh...
متن کاملSorting Out Sound
Speech analysis is a prototypical categorical mechanism that has been examined behaviorally in work going back to Haskins Laboratory studies in the 1950s: such work examined the perception of continua between phonemes and demonstrated sharp discontinuities consistent with categorical perception. In this issue of Neuron, Raizada and Poldrack examine analysis mechanisms for such processing by mea...
متن کاملSorting out Zero-Knowledge
The purpose of this paper is to explain the various notions involved and to offer a new terminology that emphasizes their differences. There are two orthogonal aspects to zero-knowledge interactive proofs. One is the notion of zero-knowledge and the other is the notion of interactive proof. Unfortunately, these two notions are often thought to be inseparable. This confusion is reminiscent of th...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2011
ISSN: 0009-7330,1524-4571
DOI: 10.1161/res.0b013e31820d7daa