Sortilin mediates vascular calcification via its recruitment into extracellular vesicles
نویسندگان
چکیده
منابع مشابه
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
Vascular calcification is a common feature of major cardiovascular diseases. Extracellular vesicles participate in the formation of microcalcifications that are implicated in atherosclerotic plaque rupture; however, the mechanisms that regulate formation of calcifying extracellular vesicles remain obscure. Here, we have demonstrated that sortilin is a key regulator of smooth muscle cell (SMC) c...
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1Department of Biochemistry Medical School, Justus-Liebig-University, Giessen; 2Department of Anesthesiology, Department of Experimental Neurology, Kerckhoff-Klinik, Bad Nauheim; 3Department of Neurology, Medical School, Justus-Liebig-University, Giessen; 4Department of Radiology, Department of Experimental Neurology, Kerckhoff-Klinik, Bad Nauheim; 5Core Lab for Molecular and Structural Biology...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2016
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci80851