Sonohysterography for evaluation of endometrial abnormalities associated with tamoxifen therapy for breast cancer

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Sonohysterography for evaluation of endometrial abnormalities in breast cancer patients under tamoxifen therapy

Introduction: Tamoxifen may have secondary adverse effects on the endometrium. The aim of this study was to investigate the endometrial evaluation in women with breast cancer under tamoxifen therapy with Saline infusion Sonohysterography (SIS). Materials and Methods: This cross-sectional study was performed on 40 breast cancer patients under adjutant tamoxifen (20 mg/day for at least 6 months) ...

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evaluation of saline sonohysterography findings in patients with breast cancer receiving tamoxifen adjuvant therapy

background: transvaginal ultrasound is one of the most common means to examine endometrial cavity lesions although its negative results are more valuable. saline sonohysterography can reduce the number of false negative rates of endometrial lesions diagnoses in tamoxifen consumers. the objective of this study was to determine the diagnostic values of saline infusion sonohysterography (sis) and ...

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Tamoxifen therapy for breast cancer and endometrial cancer risk.

BACKGROUND Tamoxifen is effective in treating breast cancer, reduces breast cancer incidence among high-risk women, and is associated with increased endometrial cancer risk. This study was designed to examine the possible modifying effects of endometrial cancer risk factors on the tamoxifen-endometrial cancer association. METHODS We conducted a case-control study of endometrial cancer (324 ca...

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Trastuzumab therapy for tamoxifen-stimulated endometrial cancer.

A novel in vivo model of tamoxifen-stimulated endometrial cancer was developed and the role of HER-2/neu investigated by using trastuzumab. Tamoxifen-stimulated tumors (ECC-1TAM) were growth stimulated by 17beta-estradiol (E2), tamoxifen, or raloxifene. Trastuzumab inhibited growth of E2-stimulated ECC-1E2 tumors by 50% and tamoxifen-stimulated ECC-1TAM tumors by 100%. ECC-1 tumors expressed fu...

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Malignant Mixed Mullerian Tumor of the Uterus Associated with Tamoxifen Therapy in a Patient with a History of Breast Cancer

Tamoxifen is the drug of choice in the treatment of breast cancer.   Recent reports show an increased incidence of endometrial carcinoma in patients taking tamoxifen.   In this article, we report a case of malignant mixed mullerian tumor after tamoxifen use.

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ژورنال

عنوان ژورنال: The Egyptian Journal of Radiology and Nuclear Medicine

سال: 2013

ISSN: 0378-603X

DOI: 10.1016/j.ejrnm.2013.07.001