Sonic Hedgehog Regulates Bone Fracture Healing

Sonic Hedgehog Regulates Osteoblast Function by Focal Adhesion Kinase Signaling in the Process of Fracture Healing

Several biological studies have indicated that hedgehog signaling plays an important role in osteoblast proliferation and differentiation, and sonic hedgehog (SHH) expression is positively correlated with phosphorylated focal adhesion kinase (FAK) Tyr(397). However, the relationship between them and their role in the process of normal fracture repair has not been clarified yet. Immunohistochemi...

Sonic diagnosis of bone fracture healing--a preliminary study.

The definition of bone fracture healing onset, progress and extent is a difficult clinical diagnosis. Available criteria of manual stability, X-ray appearance, symptomatic pain and passage of time are indeed valuable, but subjective in nature. This study explores the transmission and comparative measurement of stress wave disturbances across a fracture site as a technique of quantifying the uni...

Expression and Role of Sonic Hedgehog in the Process of Fracture Healing with Aging.

Aging is one of the risk factors for delayed fracture healing. Sonic hedgehog (SHH) protein, an inducer of embryonic development, has been demonstrated to be activated in osteoblasts at the dynamic remodeling site of a bone fracture. Herein, we compared and examined the distribution patterns of SHH and the functional effect of SHH signaling on osteogenesis and osteoclastogenesis between young (...

Periosteal PTHrP Regulates Cortical Bone Remodeling During Fracture Healing.

Parathyroid hormone-related protein (PTHrP) is widely expressed in the fibrous outer layer of the periosteum (PO), and the PTH/PTHrP type I receptor (PTHR1) is expressed in the inner PO cambial layer. The cambial layer gives rise to the PO osteoblasts (OBs) and osteoclasts (OCs) that model/remodel the cortical bone surface during development as well as during fracture healing. PTHrP has been im...

Bone fracture healing pdf