Some Pharmacodynamic Aspects of Cefepime

Some Pharmacodynamic Aspects of Cefepime

Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained. Cefepime maximally stimulated isolated guinea pig's ileum, rat's colon (80 μg/mL bath), and rabbit's duodenum (400 μg/mL bath). Contrarily, complete relaxation of isolated rat's fundic strip was produced by 80 μg/mL bath. Effects of ...

Some pharmacodynamic aspects on long-acting beta-adrenoceptor agonists.

1. Formoterol and salmeterol are the first members of a new generation of long-acting beta(2)-adrenoceptor agonists for inhalation. The discovery of the long effect duration of formoterol was made by chance, while the development of salmeterol appeared to follow a purposeful research strategy. 2. Preclinical evaluation predictive of the clinical duration of effect of long-acting bronchodilators...

Ceftazidime to cefepime formulary switch: pharmacodynamic and pharmacoeconomic rationale.

Pharmacodynamic aspects of chlorpheniramine-induced bronchodilatation.

In 12 asthmatic (A) and ten normal (N) subjects, we measured the effect of inhaled saline solution, acetylcholine, histamine (H), and chlorpheniramine (CP) on specific airway conductance and forced exploratory flows. We found that CP dilated the bronchi in six asthmatic patients and one normal subject by acting on bronchial H1 receptor. This action is also modulated by the abnormal functions of...

Some combinatorial aspects of finite Hamiltonian groups

In this paper we provide explicit formulas for the number of elements/subgroups/cyclic subgroups of a given order and for the total number of subgroups/cyclic subgroups in a finite Hamiltonian group. The coverings with three proper subgroups and the principal series of such a group are also counted. Finally, we give a complete description of the lattice of characteristic subgroups of a finite H...