Some Observations of Oxygenation of C<SUB>2</SUB>- or C<SUB>3</SUB>-Oxo-5α-steroids Possessing C<SUB>1</SUB>1-Oxo-group
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چکیده
منابع مشابه
Synthesis of Novel 17-Oxo-17a-Aza-D-Homo-3, 5-Seco-Steroids as Potential 5α-Reductase Inhibitors
Benign prostatic hyperplasia (BPH) is a non-malignant enlargement of the prostate gland. Itis a leading disorder of the elderly male population. Excessive production of dihydrotestosteronehas been implicated in this pathological condition. Steroidal 5α-reductase is a membrane boundNADPH dependent enzyme which is responsible for the conversion of testosterone (T) todihydrotestosterone (DHT). The...
متن کاملsynthesis of novel 17-oxo-17a-aza-d-homo-3, 5-seco-steroids as potential 5α-reductase inhibitors
benign prostatic hyperplasia (bph) is a non-malignant enlargement of the prostate gland. itis a leading disorder of the elderly male population. excessive production of dihydrotestosteronehas been implicated in this pathological condition. steroidal 5α-reductase is a membrane boundnadph dependent enzyme which is responsible for the conversion of testosterone (t) todihydrotestosterone (dht). the...
متن کاملLuminescent rhenium fac-tricarbonyl-containing complexes of androgenic oxo-steroids.
A new route to luminescent derivatives of androgenic steroids containing a ketone group in the 3- or 17-position has been developed. Reaction with the fac-Re(CO)(3)Cl complex of 3,3'-diamino-2,2'-bipyridine (complex 1) afforded a cyclic aminal product with different steroids. The rate of reaction and yield varies according to the conjugation or steric hindrance around the ketone group.
متن کاملThe analysis of urinary 17-oxo steroids by gradient elution.
The present work was initiated by the observation of Reifenstein, Homburger & Dobriner (1950) that 3a: 1 1l-dihydroxy-5p-androstan-17-one (1 l,B-hydroxyaetiocholanolone), a minor component of the urinary 17-oxo steroids, was significantly associated with neoplastic growth. The re-examination of this problem has led to the development of a micro method for the quantitative separation and determi...
متن کاملdetection of volatile compounds of medicinal plants with some nano-sorbents using modified or new methodologies and investigation of antioxidant activity of their methanolic extracts
in this work, a novel and fast method for direct analysis of volatile compounds (davc) of medicinal plants has been developed by holding a filament from different parts of a plant in the gc injection port. the extraction and analysis of volatile components of a small amount of plant were carried out in one-step without any sample preparation. after optimization of temperature, extraction time a...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1964
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.12.1530