Some Endocrine Aspects of Skin Sensitization and Primary Irritation

Skin irritation and sensitization: mechanisms and new approaches for risk assessment. 1. Skin irritation.

Cutaneous irritation presents a major health problem with serious social and occupational impact. The interaction between an irritant and the human skin depends on multiple factors: the intrinsic properties and the nature of the irritant itself, and specific individual- and environment-related variables. The main pathological mechanisms of irritancy include skin barrier disruption, induction of...

Evaluation of dermal irritation and skin sensitization due to vitacoxib

The prediction of side-effects is a key issue in the REACH initiative on chemicals in the preclinical testing of drugs. The dermal irritation and skin sensitization toxicity potential of a new molecule, vitacoxib, were invested in rabbits and guinea pigs in compliance with the Organization for Economic Cooperation and Development guideline. To assess dermal irritation, rabbits were dermally att...

Some aspects of electron transfer sensitization systems

Some aspects of electron transfer sensitization systems not only for chemical conversion and storage of light energy but also for design of photoelectrochemical molecular device are presented. Also regarding energy conversion as one of chemical transformation of every chemical signal (information), we have been introducing and realizing the concepts of molecular electronic device. This paper in...

Skin irritation and corrosion.

Assessment of phototoxicity, skin irritation, and sensitization potential of polystyrene and TiO2 nanoparticles

The human skin equivalent model (HSEM) is well known as an attractive alternative model for evaluation of dermal toxicity. However, only limited data are available on the usefulness of an HSEM for nanotoxicity testing. This study was designed to investigate cutaneous toxicity of polystyrene and TiO2 nanoparticles using cultured keratinocytes, an HSEM, and an animal model. In addition, we also e...