Somatostatin — both hormone and neurotransmitter?

Norepinephrine: hormone and neurotransmitter in man.

To determine whether norepinephrine could subserve a hormonal as well as a neurotransmitter function, norepinephrine was infused for 60 min into each of five normal young men in doses of 0.1, 0.5, 1.0, 2.5, and 5.0 microgram/min. After infusion, the plasma norepinephrine concentration fell with a mean (+/-SD) half-time of 2.4 +/- 0.7 min. The mean (+/-SD) norepinephrine metabolic clearance rate...

Fusion pores and their control of neurotransmitter and hormone release

Ca2+-triggered exocytosis functions broadly in the secretion of chemical signals, enabling neurons to release neurotransmitters and endocrine cells to release hormones. The biological demands on this process can vary enormously. Although synapses often release neurotransmitter in a small fraction of a millisecond, hormone release can be orders of magnitude slower. Vesicles usually contain multi...

Facilitation of Neurotransmitter and Hormone Release by P2X Purinergic Receptors

Anti-idiotypic antibodies against hormone and neurotransmitter receptors.

Introduction Hormones, neurotransmitters, even viruses, exert their effects through specific receptors, most often membrane proteins. Molecular characterization of these receptors has been for years an attractive challenge for pharmacologists and the production of specific anti-receptor antibodies has appeared as a way towards this goal. Several polyclonal or monoclonal antibodies have been pre...

Structure and function of somatostatin receptors in growth hormone control.

This new generation of SRIF analogs offer exciting opportunities to improve hormone hypersecretion in patients with GH- and TSH-secreting pituitary adenomas and possibly even in patients harboring prolactinomas and non-functioning tumors. Future development of novel analogs with improved affinity for both SSTR2 and SSTR5 may have even greater potency to suppress pituitary hormone hypersecretion...