Solving the Conundrum: Immunogenetics of Sarcoidosis

Solving a Cartesian Conundrum

LIn a recent issue of this journal, Robert Oakes has proposed a “Cartesian conundrum,” arguing that certain elements in Descartes’ philosophical theology are incompatible.^ I believe that this conundrum can be solved. It does, however, lead to an interesting question about what constitutes the “materiality” of a material object. In this article I propose to solve the conun­ drum, and to say a l...

Re-solving the cadherin-catenin-actin conundrum.

Cell-cell adhesion plays critical roles in establishing and maintaining tissue architecture and function (1,2). In these roles, cell-cell adhesion must be adaptable and, depending on the biological circumstance, weak, dynamic or strong. Different adhesion structures (adherens junctions, tight junctions, desmosomes) regulate cell-cell adhesion, and each comprises distinct membranebound adhesion ...

THE CONUNDRUM OF EUTHANASIA

Coexisting Sickle Cell Anemia and Sarcoidosis: A Management Conundrum!

Sickle cell disease and Sarcoidosis are conditions that are more common in the African American population. In this report we share an unfortunate patient who had hepatic sarcoidosis but could not receive steroids since that precipitated acute liver failure. We have discussed potential therapy options but we need more options that improve mortality.

Immunogenetics Human immunogenetics Editorial overview

Charles Larsen trained as a protein chemist and has studied the biophysics of viral membrane fusion. His current interest is the cellular immunology and genetics of the human nonresponse to hepatitis B vaccine. This interest has broadened to include the relationship between MHC genetic structure and autoimmune phenomena. Abbreviations CEH conserved extended haplotype KIR killer immunoglobulin-l...