Solvent Suitability for HFPO-DA (“GenX” Parent Acid) in Toxicological Studies

Data management for toxicological studies.

Organized data management increases the reliability of statistical analysis. The basic purpose of data management is to assure the integrity and the quality of data. To assure data validity, establishing a checking system, such as data audit, would be desirable at the following points: protocol design, supervision of study schedule, definition of data, data collection, choice of tests and proce...

Toxicological Studies of Calvacin.

Calvacin is a potent, antitumor mucoprotein which is cumulative in effect and which causes a prolonged intoxication characterized by anorexia and extreme weight loss. It induces a wide spectrum of lesions in experimental mammals. The more promi nent include hepatic necrosis, biliary obstruction, renal tubular necrosis, fibrinoid degeneration, myofibrillar necrosis in cardiac and skeletal muscle...

3.6 System Integration Genx Development

Simulating solid propellant rocket motors requires solving an extremely complex, fully coupled multidisciplinary physics problem that spans a wide range of length and time scales. We have taken a staged approach in developing an integrated whole-system rocket simulation package, beginning with relatively simple physical models, geometries, and coupling in our first-generation code (GEN1), and p...

Embryonic Stem Cells in Toxicological Studies

Toxicological Characterization of Phthalic Acid

There has been growing concern about the toxicity of phthalate esters. Phthalate esters are being used widely for the production of perfume, nail varnish, hairsprays and other personal/cosmetic uses. Recently, exposure to phthalates has been assessed by analyzing urine for their metabolites. The parent phthalate is rapidly metabolized to its monoester (the active metabolite) and also glucuronid...