Solvent exposure and myelodysplastic syndrome.
نویسندگان
چکیده
منابع مشابه
Myelodysplastic syndrome.
The last decade has witnessed a multistep evolution in the understanding of the natural history, clinical manifestations, and some of the molecular mechanisms that underlie the ineffective hematopoiesis and leukemic transformation in the myelodysplastic syndrome (MDS). The international prognostic scoring system, FAB, and WHO classifications have helped define specific subgroups with their char...
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The hallmark of neoplastic disease, including myelodysplastic syndrome (MDS), is clonal proliferation of cells. Clonal proliferation is the consequence of acquired somatic mutation that confers a proliferative advantage to cells. For the myelodysplastic syndrome, the ability to identify clonally derived cells has provided valuable information about the molecular pathogenesis of the disease, the...
متن کاملMyelodysplastic syndrome.
During the past 15 years, important progress has been made in the understanding of the biology and prognosis of myelodysplastic syndrome (MDS). MDS is a clonal disorder characterized by ineffective hematopoiesis, which can lead to either fatal cytopenias or acute myelogenous leukemia (AML). Risk-adapted treatment strategies were established because of the high median age (60-75 years) of the MD...
متن کاملMyelodysplastic Syndrome patients
Large granular lymphocyte leukemia (LGL) is often associated with immune cytopenias and can co-occur in the context of aplastic anemia (AA) and myelodysplastic syndromes (MDS). We took advantage of the recent description of STAT3 mutations in LGL clonal expansions to test, using sensitive methods, for the presence of these mutations in a large cohort of 367 MDS and 140 AA cases. STAT3 clones ca...
متن کاملBenzene-induced myelodysplastic syndrome.
In various industries benzene is used for cleaning, stain removal, and dilution and as an adhesive. The petrochemical industry uses benzene as a raw material for styrene, alkyl benzene, and caprolactam. Moreover, aromatic compounds are added to gasoline as a substitute for alkyl lead compounds. Although atmospheric lead pollution is reduced, the concentration of benzene released into the air is...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Work, Environment & Health
سال: 1990
ISSN: 0355-3140,1795-990X
DOI: 10.5271/sjweh.1760