Solvent and mutation effects on the nucleation of amyloid -protein folding
نویسندگان
چکیده
منابع مشابه
Solvent and mutation effects on the nucleation of amyloid beta-protein folding.
Experimental evidence suggests that the folding and aggregation of the amyloid beta-protein (Abeta) into oligomers is a key pathogenetic event in Alzheimer's disease. Inhibiting the pathologic folding and oligomerization of Abeta could be effective in the prevention and treatment of Alzheimer's disease. Here, using all-atom molecular dynamics simulations in explicit solvent, we probe the initia...
متن کاملSolvent and mutation effects on the nucleation of amyloid {beta}-protein folding Stanley
www.pnas.org/cgi/content/full/102/51/18258#otherarticles This article has been cited by other articles: E-mail Alerts . click here at the top right corner of the article or Receive free email alerts when new articles cite this article sign up in the box Rights & Permissions www.pnas.org/misc/rightperm.shtml To reproduce this article in part (figures, tables) or in entirety, see: Reprints www.pn...
متن کاملSolvent and mutation effects on the nucleation of amyloid -protein folding
Experimental evidence suggests that the folding and aggregation of the amyloid -protein (A ) into oligomers is a key pathogenetic event in Alzheimer’s disease. Inhibiting the pathologic folding and oligomerization of A could be effective in the prevention and treatment of Alzheimer’s disease. Here, using all-atom molecular dynamics simulations in explicit solvent, we probe the initial stages of...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0509276102