Soluble thrombomodulin concentration is raised in scleroderma associated pulmonary hypertension
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چکیده
منابع مشابه
Soluble thrombomodulin concentration is raised in scleroderma associated pulmonary hypertension.
OBJECTIVE To investigate the expression of thrombomodulin in scleroderma associated pulmonary hypertension. METHODS Soluble thrombomodulin (sTM), was measured in plasma samples from 34 scleroderma patients shown to have pulmonary hypertension at echocardiogram, and comparison drawn against samples from 38 scleroderma control patients, and 20 healthy controls. Serial measurements of sTM were p...
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Cardiac disease is the main cause of death in both forms of thalassemia; thalassemia major (TM) and thalassemia intermedia (TI). Pulmonary hypertension (PH) is one of the cardiopulmonary morbidities with high mortality that, if not treated, may trigger right-sided heart failure and premature death. PH is defined as a mean pulmonary artery pressure of ≥25 mmHg at rest or ≥30 mmHg during exercise...
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OBJECTIVE Identification of prognostic factors for survival in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) is necessary for appropriate monitoring, interventions, and timely referral for lung transplantation. Our objectives were (1) to identify factors associated with survival in SSc-PAH and (2) to evaluate the methodologic quality of prognostic studies against curre...
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The aim of the present study was to investigate the presence of anti-fibroblast antibodies in patients with idiopathic or scleroderma-associated pulmonary arterial hypertension (PAH) and healthy controls. PAH was documented by right-heart catheterisation (mean pulmonary artery pressure at rest >25 mmHg). Serum immunoglobulin (Ig)G and IgM reactivities of patients with idiopathic PAH (n = 35), s...
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STUDY OBJECTIVES To determine whether primary pulmonary hypertension (PPH) is associated with scleroderma-like changes in nailfold capillaries. DESIGN Blinded, prospective, case-control study. SETTING University medical centers in Baltimore, MD. PATIENTS Thirty-seven patients with PPH, 15 patients with scleroderma, and 13 healthy control subjects. MEASUREMENTS Subjects underwent nailfol...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2000
ISSN: 0003-4967
DOI: 10.1136/ard.59.2.132