Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression.
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Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression
The hyaluronan (HA) receptor RHAMM is an important regulator of cell growth. Overexpression of RHAMM is transforming and is required for H-ras transformation. The molecular mechanism underlying growth control by RHAMM and other extracellular matrix receptors remains largely unknown. We report that soluble RHAMM induces G2/M arrest by suppressing the expression of Cdc2/Cyclin B1, a protein kinas...
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[This corrects the article DOI: 10.1371/journal.pone.0113283.].
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1996
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.183.4.1663