Soluble guanylyl cyclase activators increase the expression of tolerance to morphine analgesic effect
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چکیده
منابع مشابه
Dual effect of topiramate on the expression of tolerance to analgesic effects of morphine in mice
Introduction: Topiramate is an anti-convulsant drug, which produces its effects via glutamate metabotropic receptors inhibition and/or GABA receptor excitation. In the present study, attempts were made to investigate the effects of topiramate on the tolerance to morphine-induced analgesia activity in male NMRI mice (20-30 g). Methods: Hot plate method was chosen for the study. First of all t...
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The alpha1- and beta1-subunits of human soluble guanylate cyclase (sGC) were coexpressed in the Sf9 cells/baculovirus system. In addition to the native enzyme, constructs with hexahistidine tag at the amino and carboxyl termini of each subunit were coexpressed. This permitted the rapid and efficient purification of active recombinant enzyme on a nickel-affinity column. The enzyme has one heme p...
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ژورنال
عنوان ژورنال: Bratislava Medical Journal
سال: 2014
ISSN: 1336-0345
DOI: 10.4149/bll_2014_066