Soluble Fas mRNA is dominantly expressed in cases with silicosis
نویسندگان
چکیده
منابع مشابه
FAS Ligand Triggers Pulmonary Silicosis
We investigated the role of Fas ligand in murine silicosis. Wild-type mice instilled with silica developed severe pulmonary inflammation, with local production of tumor necrosis factor (TNF)-alpha, and interstitial neutrophil and macrophage infiltration in the lungs. Strikingly, Fas ligand-deficient generalized lymphoproliferative disease mutant (gld) mice did not develop silicosis. The gld mic...
متن کاملAqueous Humor Levels of Soluble Fas and Fas-ligand in Patients with Primary Open Angle and Pseudoex-foliation Glaucoma
Background: Glaucoma is one of the most common causes of blindness and is usually associated with elevated intraocular pressure. In patients with primary open angle glau-coma the number of trabecular meshwork cells is decreased. Death of the trabecular meshwork cells may be a result of apoptosis. Objective: To investigate the aqueous humor levels of soluble Fas (sFas) and Fas-Ligand (sFasL) in ...
متن کاملSoluble Fas ligand and soluble Fas in ocular fluid of patients with uveitis.
AIMS To investigate the presence of soluble Fas ligand (sFasL) and soluble Fas (sFas) in ocular fluid of patients with uveitis. METHODS Samples of aqueous humour (AH, n=17), vitreous fluid (n=9), and serum (n=60) were collected from patients with uveitis which included Behçet's disease, Vogt-Koyanagi-Harada disease, sarcoidosis, human T lymphotropic virus type 1 (HTLV-I) uveitis, sympathetic ...
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Pemphigus is a blistering disease characterized by pemphigus autoantibodies (PVIgG) directed mostly against desmogleins (Dsgs), resulting in the loss of keratinocyte adhesion (acantholysis). Yet, the mechanisms underlying blister formation remain to be clarified. We have shown previously that anti-Fas ligand (FasL) antibody (Ab) prevents PVIgG-induced caspase-8 activation and Dsg cleavage in hu...
متن کاملSoluble Fas and cancer.
Recent studies have revealed an anticipated link between a soluble receptor antagonist for the proapoptotic protein Fas and cancer. In this issue, Ugurel et al. (1) demonstrate that sFas levels correlate with poor prognosis and decreased overall survival in patients with melanoma. On the basis of available evidence, it appears that nonhematopoietic tumor development and progression may represen...
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ژورنال
عنوان ژورنال: Immunology
سال: 1998
ISSN: 0019-2805,1365-2567
DOI: 10.1046/j.1365-2567.1998.00509.x