Solubility and Dissolution Enhancement of Ebastine by Surface Solid Dispersion Technique
نویسندگان
چکیده
Ebastine (EBS) is a non-sedating antihistamine with long duration of action. This drug has predominantly hydrophobic property causing low solubility and bioavailability. Surface solid dispersions (SSD) an effective technique for improving the dissolution rate poorly soluble drugs by using hydrophilic water insoluble carriers.
 The present study aims to enhance EBS surface dispersion technique. Avicel® PH101, PH 102, croscarmellose sodium(CCS) sodium starch glycolate(SSG) were used as SSD formulations prepared solvent evaporation method in different drug: carrier weight ratios evaluated their percentage yield, content , solubility, 0.1 N HCl, crystal lattice powder X-ray diffraction (PXRD) Fourier Transform Infrared Spectroscopy (FTIR) determination drug-carrier interaction.
 Most formulas showed improvement solubility. best result was obtained formula SSD16 (EBS:CCS 1:15) that high yield (98.5%), (98.39%) 8.2 fold increase compared pure improved rate. converted amorphous form without chemical interaction carrier.
منابع مشابه
Solubility and Dissolution Enhancement of Etoricoxib by Solid Dispersion Technique Using Sugar Carriers
The aim of the present study was to improve solubility and dissolution of the poorly aqueous soluble drug, etoricoxib by solvent evaporation technique using various sugar carriers, such as lactose, sucrose, and mannitol. Etoricoxib solid dispersions and their respective physical mixtures using lactose, sucrose, and mannitol were prepared in different ratios by solvent evaporation technique. The...
متن کاملEnhancement of Dissolution Rate of Efavirenz by Solid Dispersion Technique
Efavirenz is an HIV-1 specific, non-nucleoside reverse transcriptase inhibitor (NNRTI).It is an antiretroviral agent indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection, which is not soluble in water and lower absorption in gastric fluid. In order to improve the solubility and oral absorption of the drug in gastric fluid and to enhance its dissolution rate, soli...
متن کاملEnhancement of dissolution rate of etoricoxib through solid dispersion technique
Etoricoxib, a non-steroidal anti-inflammatory drug, is used to Osteoarthritis, Rheumatoid arthritis and Acute Gouty arthritis. Etoricoxib is practically insoluble in water; hence present study was carried out to enhance dissolution properties of Etoricoxib through the preparation of Solid Dispersions using PEG 6000 as carrier at various proportions by using different techniques like Physical mi...
متن کاملSurface Solid Dispersion of Glimepiride for Enhancement of Dissolution Rate
Surface solid dispersions using water-insoluble carriers like crospovidone, croscarmellose sodium, sodium starch glycolate, pre-gelatinized starch, potato starch and Avicel PH 101 were investigated to enhance the dissolution rate of the glimepiride, a poorly water insoluble drug. The effect of various carriers on dissolution profile was studied using presence absence model. The surface solid di...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Iraqi Journal of Pharmaceutical Sciences
سال: 2021
ISSN: ['1683-3597', '2521-3512']
DOI: https://doi.org/10.31351/vol30iss1pp122-132