Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin
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چکیده
منابع مشابه
single-step synthesis of multi-component spirobarbiturates using ionic liquids and synthesis of substituted pyridine filled with catalysts supported on solid substrate
in this thesis, a better reaction conditions for the synthesis of spirobarbiturates catalyzed by task-specific ionic liquid (2-hydroxy-n-(2-hydroxyethyl)-n,n-dimethylethanaminium formate), calcium hypochlorite ca(ocl)2 or n-bromosuccinimide (nbs) in the presence of water at room temperature by ultrasonic technique is provided. the design and synthesis of spirocycles is a challenging task becaus...
15 صفحه اولA total solid-phase synthesis of DILP8.
We have developed a cysteine anchoring method for the synthesis of DILP8 and its analogues. The first is to synthesis of DILP8A SS13-18, C14-MeOBzl, C24-Acm and activate it as DILP8A S13-18, C14-SSPyr C24-Acm. A next step is to synthesize the DILP8BC16-Acm. The desired peptide, DILP8 with Cys(Acm) at A-24 and B-16, was then dissolved in 75% HOAc by addition of Iodine in MeOH and 4M HCl in dioxa...
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N-4909 (1), which has a stimulating activity on apolipoprotein E secretion in humanhepatoma Hep G2 cells, was isolated from the culture broth of Bacillus sp. No. 4691 by Hiramoto et al.l) This compound (1) was also isolated from Bacillus sp. A1238 as an inhibitor of acyl-CoA; cholesterol acyltransferase by Hasumi et al.2) This cyclooctadepsipeptide (1) and its diastereomer were synthesized for ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2009
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2009.57