Solid lipid nanoparticles of a water soluble drug, ciprofloxacin hydrochloride

Solid Lipid Nanoparticles of a Water Soluble Drug, Ciprofloxacin Hydrochloride

The aim of this study was to understand and investigate the relationship between experimental factors and their responses in the preparation of ciprofloxacin hydrochloride based solid lipid nanoparticles. A quadratic relationship was studied by developing central composite rotatable design. Amount of lipid and drug, stirring speed and stirring time were selected as experimental factors while pa...

solid lipid nanoparticles of ciprofloxacin hydrochloride with enhanced antibacterial activity

Formulation and evaluation of solid lipid nanoparticles of a water soluble drug: Zidovudine.

The present investigation was undertaken to develop solid lipid nanoparticles (SLN) of a hydrophilic drug Zidovudine (an anti-human immunodeficiency viral agent) and improve the entrapment efficiency of the drug in SLN. The SLN were prepared with stearic acid by process of w/o/w double-emulsion solvent-evaporation method using 3(2) factorial design. Different triglycerides alone and in differen...

Formulation and Evaluation of Solid Lipid Nanoparticles of Water Soluble Drug: Isoniazid

The Solid lipid nanoparticles (SLN) of hydrophilic dug isoniazid (INH), a first line antubericular drug are developed and the entrapment efficiency of drug in the SLN has been improved. The poor incorporation of watersoluble drugs is the problem associated with the incorporation of hydrophilic drugs in to SLN. The SLNs were prepared by ethanol injection method using tristearin and phospholipon ...

Solid Lipid Nanoparticles : an Effective Lipid Based Technology for Poorly Water Soluble Drugs

Solid lipid nanoparticles (SLNs) are the effective lipid based colloidal carriers which were introduced as an alternative to the conventional carriers such as microemulsions, liposomes, microparticles and nanoparticles based on synthetic polymers or natural macromolecules. Typically they enhance the oral bioavailability of the low aqueous soluble drugs due to their potential to enhance gastroin...