Solid Lipid Nanoparticle Carrier Platform Containing Synthetic TLR4 Agonist Mediates Non-Viral DNA Vaccine Delivery
نویسندگان
چکیده
منابع مشابه
Recent Advances in Solid Lipid Nanoparticle Based Drug Delivery Systems
Delivering the drug accurately and safely to its target site at the precise time period to have a controlled release and attain the maximum therapeutic effect remains a benchmark in the design and development of newer drug delivery systems. In this review, the latest research developments of the Solid lipid nanoparticles (SLNs) according to the recent relevant literatures were focussed. This pa...
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Technologies that delivery antigen-encoded plasmid DNA (pDNA) to antigen presenting cell and their immune-activation are required for the success of DNA vaccines. Here we report on an artificial nanoparticle that can achieve these; a multifunctional envelope-type nanodevice modified with KALA, a peptide that forms α-helical structure at physiological pH (KALA-MEND). KALA modification and the re...
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Solid lipid nanoparticle (SLN) delivery systems have a wide applicability in the delivery of phyto-bioactive compounds to treat various chronic diseases, including diabetes, cancer, obesity and neurodegenerative diseases. The multiple benefits of SLN delivery include improved stability, smaller particle size, leaching prevention and enhanced lymphatic uptake of the bioactive compounds through o...
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Targeted gene delivery systems have attracted great attention due to their potential in directing the therapeutic genes to the target cells. However, due to their low efficiency, most of the successful applications of polymeric vectors have been focused on genes which can achieve robust expression. Minicircle DNA (mcDNA) is a powerful candidate in terms of improving gene expression and prolongi...
متن کاملTargeted minicircle DNA delivery using folateepoly(ethylene glycol)e polyethylenimine as non-viral carrier
Targeted gene delivery systems have attracted great attention due to their potential in directing the therapeutic genes to the target cells. However, due to their low efficiency, most of the successful applications of polymeric vectors have been focused on genes which can achieve robust expression. Minicircle DNA (mcDNA) is a powerful candidate in terms of improving gene expression and prolongi...
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ژورنال
عنوان ژورنال: Vaccines
سال: 2020
ISSN: 2076-393X
DOI: 10.3390/vaccines8030551