Softening of the Spinal Cord

[Longitudinally extensive spinal cord lesion associated with intramedullary metastasis on MRI may represent pencil-shaped softening of the spinal cord].

(臨床神経 2011;51:433) 2010 年 11 月 1 日 拝啓 本誌第 50 巻 10 号に掲載されました短報「急性発症の longitudinally extensive spinal cord lesion を呈した転移性脊髄 髄内腫瘍」 (臨床神経 2010;50:725-727)を興味深く拝読 いたしました.Th11 椎体レベルの転移性脊髄髄内腫瘍に ともない,MRI で上位胸髄から脊髄円錐まで髄内にT2高信 号病変,すなわち longitudinally extensive spinal cord lesion (LESCL)をきたし,さらに髄内腫瘍切除後この病変は消失し たというものです.著者らはこの頭尾側に長大に伸びる髄内 病変を,髄内腫瘍にともなう脊髄浮腫であろうと考察してい ます.私はこのMRI 上の髄内腫瘍と連続する LESCLは,病 理学的には脊髄鉛...

Epidermal cyst in the spinal cord of a lamb

W5: Animal Models of Spinal Cord Injury

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A clinically oriented experiment on the effect of mixed culture of neonate spinal cord transplantation on recovery of spinal cord injury

In spinal cord injuries, direct trauma by edges of sublaxated or dislocated vertebrae and indirect ischemia as a result of vascular injury necrotize the neural tissue. After spinal cord injury, tissue loss appears as micro- or macrocavitation. Accumulations of non-neuronal cells substitute spared tissue and halts axon regrowth. Lack of supporting cells (secreting trophic factors and matrix) agg...

EFFECTS OF CIS APRIDE ON CONS TIPATION DUE TO SPINAL CORD INJURY: REPORT OF FIVE WARFARE SPINAL CORD INJURED PATIENTS

Five warfare spinal cord injured patients with intractable constipation are described. Treatment with cisapride (4 x 10 mg daily) was undertaken. The agent cisapride significantly reduced the oral-anal transit time from 25.2 days to 14.4 days. It also improved other subjective complaints of these patients markedly. No side effects were seen during the trial.