Sodium tungstate activates glycogen synthesis through a non-canonical mechanism involving G-proteins

A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5

Hepatic autonomic nerves regulate postprandial hepatic glucose uptake, but the signaling pathways remain unknown. We tested the hypothesis that serotonin (5-hydroxytryptamine [5-HT]) exerts stimulatory and inhibitory effects on hepatic glucose disposal. Ligands of diverse 5-HT receptors were used to identify signaling pathway(s) regulating glucose metabolism in hepatocytes. 5-HT had stimulatory...

Mechanism Underlying Hepatic Glycogen Synthesis

Angiotensin II activates collagen I gene through a mechanism involving the MAP/ER kinase pathway.

Vascular remodeling and rearrangement of the extracellular matrix formation are among the major adaptive mechanisms to chronic increase in blood pressure. In previous studies we have found that angiotensin II (Ang II) participates in the hypertension-associated aortic and renal vascular fibrosis by stimulating collagen type I formation. The purpose of the present study was to gain insight into ...

Estradiol activates epithelial sodium channels in rat alveolar cells through the G protein-coupled estrogen receptor.

Female sex predisposes individuals to poorer outcomes during respiratory disorders like cystic fibrosis and influenza-associated pneumonia. A common link between these disorders is dysregulation of alveolar fluid clearance via disruption of epithelial sodium channel (ENaC) activity. Recent evidence suggests that female sex hormones directly regulate expression and activity of alveolar ENaC. In ...

Realization of Synergism in Sodium Tungstate-Zn

The aim of this present work is to study, the corrosion behavior of carbon steel in well water in the presence of sodium tungstate (ST)-Zn 2+ -N-(phosphenomethyl) iminodiaceticacid (NPMIDA) solutions. Electrochemical studies and FTIR spectral studies and weight loss study have been employed. It was found that the inhibition efficiency (IE) of ST (50 ppm)-Zn 2+ (10 ppm) was improved from 8% to 8...