SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer

The small nuclear ribonucleoprotein polypeptides B And B′ (SNRPB) is a core component of spliceosome and plays key role in pre-mRNA splicing. Emerging evidence suggests that it involves the development several types cancer. Our previous study has demonstrated SNRPB highly expressed non-small-cell lung cancer (NSCLC) functions as an oncogene. However, whether contributes to cisplatin resistance NSCLC still unknown. In this study, we found negatively regulates cells. Knocking out could significantly decrease cisplatin-induced cell growth inhibition, cycle arrest apoptosis H1299 enforced expression H460 cells can markedly promote apoptosis. results also indicate overexpression enhances inhibitory effects on cell-mediated xenograft tumors. suggest may be prediction marker for patients response cisplatin-based chemotherapy.