SnapShot: Transcription Elongation

SnapShot: Transcription Elongation

Transcription elongation is a key regulatory step in gene expression that is controlled by many proteins, and mechanisms, ranging from RNA Polymerase II pausing to cotranscriptional histone modifications.

SnapShot: Transcription Regulation: Pausing

Productive elongation Modes of P-TEFb Recruitment: TFs (e.g., MYC, NF-κB) Mediator (Med26 subunit or Cdk8 module) Acetylated histones and Brd4 Other elongation factors as part of the superelongation complex CRE DNA-binding transcription factors (TFs) associate with cis-regulatory elements (CRE) to promote assembly of the PIC. TFs can stimulate PIC formation directly through interactions with th...

Transcription elongation

SnapShot: Forkhead Transcription Factors II

FOXM1 (12p13.33) GLI1, doxorubicin, NRAS, fulvestrant, butyric acid, FGF7, CDKN1A, YY1, MSA, vitamin D3, TNFSF11, IL6, CDC2 CDC25B, CENPA, AURKB, CCNA2, CCNF, CENPB, BIRC5, CCNB1, CDKN1A, ESR1, ADAM17, GLB1 Controls progression into S phase; regulates genes required for mitotic entry; liver development. Reduced hepatoblast and cardiomyocyte mitosis, ventricular hypoplasia. Die perinatally. Upre...

Single molecule transcription elongation.

Single molecule optical trapping assays have now been applied to a great number of macromolecular systems including DNA, RNA, cargo motors, restriction enzymes, DNA helicases, chromosome remodelers, DNA polymerases and both viral and bacterial RNA polymerases. The advantages of the technique are the ability to observe dynamic, unsynchronized molecular processes, to determine the distributions o...