منابع مشابه
SnapShot: The Intestinal Crypt
Intestinal organoids provide a convenient and physiologically relevant in vitro model system to study the intestinal epithelium. This 3D, multicellular culture system recapitulates the lumen and crypt-villus structure of the intestine, and incorporates all of the cell types found in the adult intestinal epithelium. Intestinal organoids make it easier than ever to get in vivo insight from in vit...
متن کاملStudies on Small Intestinal Crypt Epithelium
Small intestinal crypt epithelium obtained from normal fasting humans by peroral biopsy of the mucosa was studied with the electron microscope. Paneth cells were identified at the base of the crypts by their elaborate highly organized endoplasmic reticulum, large secretory granules, and small lysosome-like dense bodies within the cytoplasm. Undifferentiated cells were characterized by smaller c...
متن کاملFetal characteristics of small intestinal crypt cells.
Nine monoclonal antibodies were prepared against luminal membranes purified from rat intestinal cells at day 19 of gestation, and seven of them were found to define antigens common to adult crypt cells and fetal or embryonic intestinal epithelial cells. The FBB 2/29 antigen was first detected over the entire intestinal epithelial population at days 14-15 of gestation, a period of development ch...
متن کاملCVD: the intestinal crypt/villus in situ hybridization database
UNLABELLED The intestinal crypt/villus in situ hybridization database (CVD) query interface is a web-based tool to search for genes with similar relative expression patterns along the crypt/villus axis of the mammalian intestine. The CVD is an online database holding information for relative gene expression patterns in the mammalian intestine and is based on the scoring of in situ hybridization...
متن کاملEpithelial hedgehog signals pattern the intestinal crypt-villus axis.
Morphological development of the small intestinal mucosa involves the stepwise remodeling of a smooth-surfaced endodermal tube to form finger-like luminal projections (villi) and flask-shaped invaginations (crypts). These remodeling processes are orchestrated by instructive signals that pass bidirectionally between the epithelium and underlying mesenchyme. Sonic (Shh) and Indian (Ihh) hedgehog ...
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ژورنال
عنوان ژورنال: Cell
سال: 2013
ISSN: 0092-8674
DOI: 10.1016/j.cell.2013.02.030