SnapShot: Nuclear Receptors II

SnapShot: Nuclear Receptors II

Estrogen-related receptors* ERRα/NR3B1; ERRβ/NR3B2; ERRγ/NR3B3 All major systems with specific isoforms showing peaks of expression in metabolic tissues (ERRα and ERRβ) and the CNS (ERRγ) Structurally homologous to estrogen receptors; bind EREs but not activated by estrogens; modulate the expression of enzymes involved in adipogenesis, energy metabolism, and synthesis of lipids, eicosanoids, an...

SnapShot: Nuclear Receptors I

Estrogen receptors* ERα/NR3A1; ERβ/NR3A2 Endogenous: 17β-estradiol Regulation of cell growth and proliferation in multiple tissues (e.g., female reproductive tissues, bone, and CNS) Cancer, cardiovascular, immune and inflammatory, metabolic, neurological, reproductive ↑ MYC, NGF, BCL2, CXCL2, IGF1, TYMS; ↓ CD36, NDRG1, NCOR1, NCOA3 Clinical: Mixed agonists (e.g. tamoxifen, raloxifene, and torem...

SnapShot: The Nuclear Envelope II

Nup107 Nup107 CG6743 NPP-5 Nup107 SPBC428.01c Nup84 Nup96 Nup96 CG10198 NPP-10C Nup189C SPAC1486.05 Nup145C Nup85 (PCNT1) Nup75 CG5733 NPP-2 Nup-85 SPBC17G9.04c Nup85 Seh1 Nup44A CG8722 NPP-18 Seh1 SPAC15F9.02 Seh1 Sec13 Sec13 CG6773 Npp-20 Sec13 SPBC215.15 Sec13 Nup37 tbd CG11875 – tbd SPAC4F10.18 – Nup43 Nup43 CG7671 C09G9.2 – – – Centrin-21 tbd CG174931, CG318021 R08D7.51 Cdc311 SPCC1682.04 ...

Nuclear receptors. II. Intestinal corticosteroid receptors.

Two corticosteroid receptors have been cloned; they are the glucocorticoid receptor and the mineralocorticoid receptor. These receptors are members of the steroid/thyroid/retinoid receptor family of nuclear transactivating factors, which are characterized by two highly conserved zinc fingers in the central DNA binding domain, a COOH-terminal domain that encompasses the ligand binding site, and ...

SnapShot: Pattern-Recognition Receptors