منابع مشابه
SnapShot: Lung Cancer Models
K-ras activation K-rasLSL-G12D or K-rasLSL-G12V Cre-dependent expression of oncogenic K-rasG12D or K-rasG12V from endogenous locus. Viral cre delivery via adenoviral or lentiviral inoculation (intranasal or intratracheal). Adenocarcinoma spectrum histology (i.e., in situ and invasive neoplasia) in lung; metastasis not reported. K-ras somatic mutations identified in ~20%30% of lung adenocarcinom...
متن کاملSnapShot: non-small cell lung cancer.
MEK MEK162 GDC-0973 GSK1120212 MSC1936369B STAT3 OPB51602 AKT MK2206 Stage a Est. % General treatment recommendations 5-year overall survival b clinical stage path. stage IA 14% Surgical resection 50% 73% IB 10% Surgical resection, can consider adjuvant chemotherapy in selected cases (e.g. tumor size > 4cm) 43% 58% IIA 6% Surgical resection followed by adjuvant chemotherapy 36% 46% IIB 5% Surgi...
متن کاملSnapShot: Genetic Mouse Models of Cancer
p 53 T um o r S up p re ss o r Trp53 mouse germline knockout. Trp53−/− homozygous: 100% tumor penetrance at ?4.5 months. Typical tumors: T cell lymphoma (>60%); soft tissue sarcoma (?25%); osteosarcoma, brain tumors, teratoma (together <15%); carcinomas rarely observed. Trp53+/− heterozygous: 50% tumor penetrance at 17 months. Typical tumors: T cell lymphoma (?30%); soft tissue sarcoma (?30%); ...
متن کاملSnapShot: Cancer Vaccines
This SnapShot illustrates the main concepts and underlying biology of therapeutic vaccination in cancer. Dendritic cells (DCs) are an essential component of vaccination through their capacity to capture, process, and present antigens to T cells. We have come a long way in our understanding of what is needed to elicit therapeutic immunity when cancer escapes the natural barrier of protective imm...
متن کاملSnapShot: cancer metabolism pathways.
See online version for legend and references. 466 Cell Met. 17-3, March 5, 2013 ©2013 Elsevier Inc. DOI http://dx.doi.org/10.1016/j.cmet.2013.02.016 enzyme Oncogenic alteration functional outcome PFKFB3 The PFK2 isoform PFKFB3 is highly expressed in several human cancers, including colon, prostate, breast, ovary, and thyroid. Most PFK2 isoforms both generate and degrade F-2,6-bisP, which activa...
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ژورنال
عنوان ژورنال: Cell
سال: 2012
ISSN: 0092-8674
DOI: 10.1016/j.cell.2012.03.015