SnapShot: Human Biomedical Genomics

SnapShot: Human Biomedical Genomics

Single-nucleotide variation (SNV) When a single base pair (A, C, T, G) is observed to vary in a DNA sequence. This variant may be private to an individual or family. For biallelic SNVs (i.e., an SNV that exists in two possible states), an individual can carry three possible allelic combinations or genotypes on their two chromosomes (e.g., for a single base pair position that could be A or G, th...

Comparative genomics of human stem cell factor (SCF)

Stem cell factor (SCF) is a critical protein with key roles in the cell such as hematopoiesis, gametogenesis and melanogenesis. In the present study a comparative analysis on nucleotide sequences of SCF was performed in Humanoids using bioinformatics tools including NCBI-BLAST, MEGA6, and JBrowse. Our analysis of nucleotide sequences to find closely evolved organisms with high similarity by NCB...

Advances in Swine Biomedical Model Genomics

This review is a short update on the diversity of swine biomedical models and the importance of genomics in their continued development. The swine has been used as a major mammalian model for human studies because of the similarity in size and physiology, and in organ development and disease progression. The pig model allows for deliberately timed studies, imaging of internal vessels and organs...

Biomedical Information Integration Middleware for Clinical Genomics

Clinical genomics, the marriage of clinical information and knowledge about the human or pathogen genome, holds enormous promise for the healthcare and life sciences domain. Based on a more in-depth understanding of the human and pathogen molecular interaction, clinical genomics can be used to discover new targeted drugs and provide personalized therapies with fewer side effects, at reduced cos...

SnapShot: The Human Microbiome