SnapShot: HIV-1 Proteins

SnapShot: HIV-1 Proteins

Negative Factor, Nef Yes, cleaved by PR CD4/MHC downregulation; T-cell activation; moderate enhancer of viral infectivity; blocks apoptosis; pathogenicity determinant CD4, CD28, MHC-I, MHC-II, TCR-CD3ζ, other cell-surface proteins Nef connects immunologically important host surface proteins to clathrin-dependent and -independent sorting pathways to regulate traffi cking, degradation, and immune...

SnapShot: FMRP Interacting Proteins

The Fragile X syndrome, caused by the absence or mutation of fragile X mental retardation protein, FMRP, is a the common component of inherited intellectual disability and autism. This SnapShot surveys the protein interaction partners of FMRP, focusing on the cellular pathways in which they are involved.

SnapShot: BCL-2 Proteins

SnapShot: Circadian Clock Proteins

SnapShot: F Box Proteins II

mammals f Box Protein substrates Biological functions of substrates kinase(s) Fbxw1/βTRCP1 (Fbxw11/ β-TrCP2) Atf4 txn factor, stress pathways β-Catenin txn activator, Wnt signaling Gsk3 BimEL BH3 homology, induces apoptosis Rsk1, Rsk2 Bora Aurora kinase activator, spindle stability Gsk3, Plk3 Cdc25A phosphatase, CDK activator, cell cycle Chk1 Cdc25B phosphatase, CDK activator, cell cycle Claspi...