منابع مشابه
Vascular smooth muscle phenotypic diversity and function.
The control of force production in vascular smooth muscle is critical to the normal regulation of blood flow and pressure, and altered regulation is common to diseases such as hypertension, heart failure, and ischemia. A great deal has been learned about imbalances in vasoconstrictor and vasodilator signals, e.g., angiotensin, endothelin, norepinephrine, and nitric oxide, that regulate vascular...
متن کاملVascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling.
Differentiated vascular smooth muscle cells (SMCs) retain the capacity to modify their phenotype in response to inflammation or injury. This phenotypic switching is a crucial component of vascular disease, and is partly dependent on epigenetic regulation. An appreciation has been building in the literature for the essential role chromatin remodelling plays both in SMC lineage determination and ...
متن کاملSmooth muscle phenotypic modulation--a personal experience.
The idea that smooth muscle cells can exist in multiple phenotypic states depending on the functional demands placed upon them has been around for >5 decades. However, much of the literature today refers to only recent articles, giving the impression that it is a new idea. At the same time, the current trend is to delve deeper and deeper into transcriptional regulation of smooth muscle genes, a...
متن کاملMolecular determinants of vascular smooth muscle cell diversity.
Although the primary role of vascular smooth muscle cells (SMCs) is contraction, they exhibit extensive phenotypic diversity and plasticity during normal development, during repair of vascular injury, and in disease states. Results of recent studies indicate that there are unique as well as common transcriptional regulatory mechanisms that control expression of various SMC marker genes in disti...
متن کاملPhenotypic Modulation of Vascular Smooth Muscle Cells:
G protein-coupled receptors regulate two major functions of vascular smooth muscle cells (SMCs) the vasomotor contractile response and the proliferative response. The contractile phenotype of SMCs has mainly been studied in situ within intact blood vessels, whereas the synthetic or proliferative SMC phenotypes can be studied in culture and represent a model of the SMC phenotype seen in vascular...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2019
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.119.312131