Smoking-promoted oxidative DNA damage response is highly correlated to lung carcinogenesis

Smoking-promoted oxidative DNA damage response is highly correlated to lung carcinogenesis

Oxidative stress induced by tobacco smoking is one of the main causes of DNA damage and is known to be involved in various cancers. Smoking is the leading cause of lung cancer, while the role of cigarette smoke-induced oxidative DNA damage response during lung carcinogenesis is largely unknown. In this study, we investigated oxidative DNA damage response levels in smoking and nonsmoking patient...

Counteracting Hexavalent Chromium-Promoted-Oxidative DNA Damage

Role of Bacillus subtilis Error Prevention Oxidized Guanine System (GO) in 1 Counteracting Hexavalent Chromium-Promoted-Oxidative DNA Damage 2 3 4 Fernando Santos-Escobar, J. Félix Gutiérrez-Corona and Mario Pedraza-Reyes 5 6 7 Department of Biology, Division of Natural and Exact Sciences, University of Guanajuato, 8 P.O. Box 187, Guanajuato, 36050, Gto. México. 9 10 11 12 13 Running Title: Rol...

Inflammation, oxidative DNA damage, and carcinogenesis.

Inflammation has long been associated with carcinogenesis, especially in the promotion phase. The mechanism of action of the potent inflammatory agent and skin promoter 12-tetradecanoyl phorbol-13-acetate (TPA) is unknown. It is thought that TPA selectively enhances the growth of initiated cells, and during this process, initiated cells progress to the preneoplastic state and eventually to the ...

Oxidative DNA damage accumulation in gastric carcinogenesis.

BACKGROUND Gastric carcinogenesis is a multifactorial, multistep process, in which chronic inflammation plays a major role. AIMS In order to ascertain whether free radical mediated oxidative DNA damage is involved in such a process, concentrations of 8-hydroxydeoxyguanosine (8OHdG), a mutagenic/carcinogenic adduct, and thiobarbituric acid reactive substances (TBARS), as an indirect measure of...

Oxidative DNA Damage and Pro-inflammatory Response In Chronic Exposure To Cement Dust