Small proteins: untapped area of potential biological importance

Small proteins: untapped area of potential biological importance

Polypeptides containing ≤100 amino acid residues (AAs) are generally considered to be small proteins (SPs). Many studies have shown that some SPs are involved in important biological processes, including cell signaling, metabolism, and growth. SP generally has a simple domain and has an advantage to be used as model system to overcome folding speed limits in protein folding simulation and drug ...

Untapped Potential for Cardiac Repair

An explosion of interest in new therapies for heart repair has occurred recently. Most notably, clinical trials of cell-based cardiovascular therapy have garnered much attention, and preliminary results are encouraging. However, the mechanism of action of cell-based therapies remains unclear, and many details with regard to characterization, quality control, and delivery of cells remain to be w...

INTERACTION OF PROTEINS WITH SMALL MOLECULES

The Untapped Potential of IT Chargeback

IT chargeback is generally regarded as a necessary evil in which central IT costs are, as accurately as possible, divided among the business units that benefit from them. In this study of IT chargeback practices at ten large U.S. firms, we found that IT chargeback had the potential to be a valuable management tool. We observed three approaches to chargeback that differed according to their obje...

Untapped potential of health impact assessment.

The World Health Organization has promoted health impact assessment (HIA) for over 20 years. At the 2012 United Nations Conference on Sustainable Development (Rio+20), HIA was discussed as a critical method for linking health to "green economy" and "institutional framework" strategies for sustainable development. In countries having a high human development index (HDI), HIA has been added to th...