Small-molecule FGF trap shrinks tumours

shrinks even small worlds

We consider small world graphs as defined by Kleinberg (2000), i.e., graphs obtained from a ddimensional mesh by adding links chosen at random according to the d-harmonic distribution. In these graphs, greedy routing performs in O(log2 n) expected number of steps. We introduce indirect-greedy routing. We show that giving O(log2 n) bits of topological awareness per node enables indirect-greedy r...

Eclecticism Shrinks the World

Small Intestinal Tumours

Objective. Balloon enteroscopy (BE) and capsule enteroscopy (CE) are enteroscopy methods that allow examination and treatment of the small bowel. Before the CE and BE era, the small intestine was difficult to access for investigation. Small intestinal tumours are infrequent conditions, but about half of them are malignant. Materials and Methods. A total of 303 BEs were performed in 179 patients...

Small Intestinal Neuroendocrine Tumours

Edfeldt, K. 2014. Small Intestinal Neuroendocrine Tumours. Genetic and Epigenetic Studies and Novel Serum Biomarkers. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 975. 51 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8887-1. Small intestinal neuroendocrine tumours (SI-NETs) are rare, hormone producing and proliferate slowly. Patients usual...

Anaplastic Lymphoma Kinase: role in specific tumours, and development of small molecule inhibitors for cancer therapy.

The Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase first identified as the product of a gene rearrangement in Anaplastic Large Cell Lymphoma. ALK has subsequently been found to be rearranged, mutated, or amplified in a further series of tumours including neuroblastoma, and Non-Small Cell Lung Cancer. There is strong preclinical evidence that ALK is a driving force for oncogenesi...