Small-molecule control of protein function through Staudinger reduction
نویسندگان
چکیده
منابع مشابه
Small Molecule Control of Protein Function through Staudinger Reduction
Using small molecules to control the function of proteins in live cells with complete specificity is highly desirable, but challenging. Here we report a small-molecule switch that can be used to control protein activity. The approach uses a phosphine-mediated Staudinger reduction to activate protein function. Genetic encoding of an ortho-azidobenzyloxycarbonyl amino acid using a pyrrolysyl tran...
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ژورنال
عنوان ژورنال: Nature Chemistry
سال: 2016
ISSN: 1755-4330,1755-4349
DOI: 10.1038/nchem.2573