Small Literature as a Problem. Could It Be Solved?

The protein folding problem: when will it be solved?

The protein folding problem can be viewed as three different problems: defining the thermodynamic folding code; devising a good computational structure prediction algorithm; and answering Levinthal's question regarding the kinetic mechanism of how proteins can fold so quickly. Once regarded as a grand challenge, protein folding has seen much progress in recent years. Folding codes are now being...

Could a combinatorial optimization problem be solved by a differential equation ?

Abstract. For the Traveling Salesman Problem ( ), a combinatorial optimization problem, a feedforward artificial neural network model, the Continuous Hopfield Network ( ) model, is used to solve it. This neural network approach is based on the solution of a differential equation. An appropriate parameter setting of this differential equation can assure that the solution is associated with a tou...

A pelvic mass in a 10-year-old: could it be a Hydatid Cyst?

This article reports a pelvic hydatid cyst in a 10-year-old boy who initially presented with right flank pain. Computed tomography (CT) revealed a cystic lesion containing internal densities, which was found to be a hydatid cyst between the bladder and rectum during surgery. The lesion was excised and sent to a pathology laboratory for further examination.

The protein structure prediction problem could be solved using the current PDB library.

For single-domain proteins, we examine the completeness of the structures in the current Protein Data Bank (PDB) library for use in full-length model construction of unknown sequences. To address this issue, we employ a comprehensive benchmark set of 1,489 medium-size proteins that cover the PDB at the level of 35% sequence identity and identify templates by structure alignment. With homologous...

Could it be Lyme neuroborreliosis?